Disadvantages of Hosting Your Own Site. Unless you have a very high-speed internet connection, your new website will be slow. You will have to purchase broadband that can react quickly, so your website works efficiently for customers. If you have a lot of traffic through your website, your internet connection may not be able to deal with this. Advantages, Disadvantages, and Experiences of One-to-one Technology in the Classroom.
Some of the Advantages and Disadvantages of Social Bookmarking are discussed below. So let us check it out some of the advantages and disadvantages to know more about Social Bookmarking which are discussed one by one:
Advantages of Social Bookmarking are:
- Person often visits same website daily, Creating a social bookmark which is available on social network helps the users to access the website easily. No need to remember the name of all the websites you visited.
- Social bookmark availabe on office computer can be available automatically on your home computer.
- If you save large number of social media networking or other websites then it is easy to find the exact website you want from your social bookmarking network.
- Social bookmaring sites helps to share files, documents, research paper or other multimedia files from social media networking sites.
- Social bookmarking sites helps to manage multiple accounts.
- You can easily share and promote your content or business via social bookmarking.
- Social bookmarking saves lots of time and effort for finding and organizing sharing websites.
- Social bookmarking allows people to share their favourite websites.
- Rich information and quality content can be created by pointing links to other relevant pages using social bookmarks.
- Sometimes it helps to bring back links to your page which may increase search engine visibility, popularity and traffic to your site.
- Social bookmarking is easy method and anyone can do it, no need for special training.
- Easy to find others favourite websites by social bookmarking.
- Bookmarking sites like diigo allows user to annotate webpages.
- Social bookmarking helps to bring instant traffic to your site.
Disadvantages of Social Bookmarking are:
- Sometimes if you bookmark number of sites on social bookmarking network, then it takes some time to find the website if you do not know the name of the required website.
- You need to manage your social bookmarking account regularly to get continuous traffic to your website.
- Some social bookmarking site are not free, you need to pay monthly charges.
- Spamming - Sometimes tagging wrong information on social bookmarking sites may mislead user.
A substantial and growing body of evidence highlights extracellular vesicles as critical components in cell-to-cell communication pathways. The visualization of EVs is fundamental to our understanding of the role of EVs in all aspects of cellular transmission; from the packaging of signaling molecules and nucleic acids during vesicle biogenesis, to tracking of their uptake and fate after internalization within selected target cells or tissues.
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Challenges in Visualizing Extracellular Vesicles
Extracellular vesicles originating from different cells or tissues are destined for specific target sites where they carry out particular functions. As EVs vary greatly in both size and protein content, it is believed that the presence of specific biomarkers (including tetraspanins, integrins and other proteins) on different sub-groups of EVs may be the root cause of this selectivity (Lyden et al 2015). However, characterizing these biomarkers on individual EVs poses a significant challenge to researchers in the field.
While electron microscopy techniques have the capability to resolve individual EVs, they do not easily allow detection of multiple markers at the same time, and are limited to fixed cells. With conventional light microscopy techniques, a number of proteins can be labeled but the small size of EVs means that the majority fall well below the resolution limit of light microscopy, restricting the usefulness of these techniques in identifying different sub-populations of vesicles.
Super-resolution for Extracellular Vesicle characterization
Super-resolution microscopy surpasses the resolution barrier of conventional light microscopes and enables detection and quantification of single proteins and nucleic acids at the sub-vesicular level. Furthermore, the structural composition of vesicle membranes can be reconstructed with single-molecule localization microscopy (SMLM) reaching 20 nm resolution and can be used to identify the specific biomolecules involved in EV signalling and targeting.
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The application of super-resolution imaging techniques has high value in identifying and visualizing sub-populations of EVs and may additionally provide important information into the role EVs play in disease progression. Read more about visualizing extracellular vesicles